The mechanism of limb segment reactive hyperemia in man.

The roles of vasodilator metabolites and/or reduced local intra-arteriolar pressure in producing the reactive hyperemia which follows the suclden release of arterial occlusion were studied. It was found that slight increases of metabolic activity during the period of occlusion increased the reactive hyperemia considerably. Maintenance of intra-arteriolar pi'essure during arterial occlusion depressed the resultant mictive hyperemia. It was concluded that both factors contribute to the reactive hyperemia. The blood flow "debt" incurred during arterial occlusion was almost invariably "overpaid" during the reactive hyperemia period.